產品描述

塔望科技提供全系列的動物實驗用低/高氧控制產品，包括恒定濃度控制的低氧動物箱、高氧動物箱、可編程的間歇氧濃度控制系統、帶緩沖艙的手套低氧箱等。整套間歇氧氧實驗箱裝置主要由氧氣控制器和動物實驗箱兩部分組成。另可提供多種不同的氣體控制器，滿足不同實驗O2、CO2、NO、CO、O3等氣體濃度控制的需求。

ProOx-100動物間歇低氧實驗系統可以控制動物實驗箱內持續低氧的環境，用以制造相關的間歇低氧實驗模型。用戶可自由設置所需要的濃度和實驗持續時間，所有的設置通過控制主機觸摸屏完成，人性化設計，操作簡便。

ProOx-100動物間歇低氧實驗系統監測指標全面，動物低氧艙內具有集成化的傳感器模塊，內置溫度、濕度、氧氣、二氧化碳傳感器?？梢詫崟r監測動物低氧艙內的環境。系統通過閉環反饋控制，根據動物低氧艙內的氧濃度實時反饋控制，使動物實驗數據更準確。Ox-100動物低氧實驗系統具有優良的控制性能，持續低氧實驗時，氧濃度的誤差為0.1%。

如需高氧實驗，請選擇型號Ox-100HE。

產品特點及參數

1. 為動物間歇低氧實驗模型的建立提供穩定的低氧環境

2. 按照設定氣體濃度自動配比氣體，無需在箱體外混合比例氣體，實驗氧濃度的準確，節省氣源

3. 艙體采用全透明PMMA材質，防止由于光線影響動物生物節律

4. 7英寸大屏觸摸屏控制，人性化界面，操作簡單

5. 監測參數：溫度、濕度、氧氣O2濃度、二氧化碳濃度

6. 控制精度：±0.1%

7. 非色散紅外（NDIR）二氧化碳傳感器，測量范圍：0～5000ppm

8. 進口電化學氧氣O2濃度檢測器，測量范圍：0-25%vol，線性度好，檢測準確、使用壽命長。具有溫度補償機制

9. 溫度檢測：進口高精度溫度傳感器

10. 氧氣濃度變化動態曲線，直觀了解氧氣濃度變化的過程

11. 具有定時功能，實驗完成，自動恢復常氧狀態，并伴有聲音提示

12. 氧氣濃度自動校準：通過控制器對傳感器快速校準

13. *的氣體混合及循環機制，保證箱體內氣體濃度的均一

14. 高性能電磁閥，性能穩定，超長壽命

15. 艙體尺寸有多種選擇，可靈活搭配。也可根據實驗要求進行定制

ProOx-100動物間歇低氧實驗系統多功能控制

可進行間歇低氧實驗（CIH）、急性缺氧實驗、慢性缺氧實驗、高氧/低氧交替實驗

應用領域

肺動脈高壓、腎臟疾病研究、腫瘤研究、心血管疾病研究、視網膜病變、運動醫學研究、OSAHS、腦發育與神經生物學、干細胞研究、醫學研究等

型號說明

艙體型號（可選擇不同尺寸的低氧艙）

引用文獻

[1]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. "Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia" . [J] International Journal of Pharmaceutics,2020,591

?[2]Guijuan Chen,Kang Cheng,Yun Niu,Li Zhu,Xueting Wang."Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-κB signaling" . [J]. Archives of Biochemistry and Biophysics ,Volume 729, 109393;

[3]Yapeng,LuPanpanChang,WangwangDing,JiangpeiBian,DanWang,XuetingWang,QianqianLuo,XiaomeiWu,LiZhu."Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells". [J]. European Journal of Pharmacology,Volume 929,2022,175137

[4]Jun-Yu Wei, Miao-Yue Hu, Xiu-Qi Chen, Feng-Ying Lei, Jin-Shuang Wei, Jie Chen, Xuan-Kai Qin & Yuan-Han Qin ."Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner" . [J]. European Journal of Pharmacology,Renal Failure, 44:1, 2056-2065

[5]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,"Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling" . [J]. Biomedicine & Pharmacotherapy, Volume 156, 2022,113982

[6]Fang Zhao, Yan Meng, Yue Wang, Siqi Fan, Yu Liu,Xiangfeng Zhang, Chenyang Ran, Hongxin Wang and Meili Lu. "Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway" . [J]. Frontiers in Pharmacology,10.3389/fphar.2022.920977

[7]Xu Y, Kong X, Li J, Cui T, Wei Y, Xu J, Zhu Y , Zhu X. “Mild Hypoxia Enhances the Expression of HIF and VEGF and Triggers the Response to Injury in Rat Kidneys." [J]. Front. Physiol. 12:690496. doi: 10.3389/fphys.2021.690496

[8]Liang Xie, Qinhan Wu, Weiping Hu, Xu Wu, Guiling Xiang, Shengyu Hao, Han Guo, Shanqun Li. “Impact of histaminergic H3 receptor antagonist on hypoglossal nucleus in chronic intermittent hypoxia conditions." [J]. Psychopharmacology. 

[9]Li Huang, Tianyou Li, Min Zhou, Mengyan Deng, Lidong Zhang, Long Yi, Jundong Zhu, Xiaohui Zhu, Mantian Mi. “Hypoxia Improves Endurance Performance by Enhancing Short Chain Fatty Acids Production via Gut Microbiota Remodeling." [J]. Front. Microbiol. 12:820691

[10]Yanhong Pei a b, Lifei Huang c, Tong Wang c, Qinhan Yao a, Yanrong Sun a, Yan Zhang a, Xiaomei Yang a, Jiliang Zhai d, Lihua Qin a, Jiajia Xue c, Xing Wang c, Hongquan Zhang a b, Junhao Yan."Bone marrow mesenchymal stem cells loaded into hydrogel/nanofiber composite scaffolds ameliorate ischemic brain injury. materialstoday ADVANCES, Volume 17, March 2023, 100349.

[11]Zhang, C., Sun, Y., Guo, Y. et al. “JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension. “[J].Cell Death Discov. 9, 98 (2023).

[12]Chenyu Xu, Jun Xu, Chunfang Zou, Qian Li, Shan Mao, Ying Shi, Yan Tan, Wei Gu, Liang Ye. "Chronic Intermittent Hypoxia Regulates CaMKII-Dependent MAPK Signaling to Promote the Initiation of Abdominal Aortic Aneurysm."  [J]. Hindawi, Oxidative Medicine and Cellular Longevity Volume 2021, Article ID 2502324, 15 pages

[13]Jing Zhang, Jian-Zhong Jiang, Jun Xu, Chen-Yu Xu, Shan Mao, Ying Shi, Wei Gu, Chun-Fang Zou, Yue-Ming Zhao,  Liang Ye. "Identification of Novel Biomarkers for Abdominal Aortic Aneurysm Promoted by Obstructive Sleep Apnea." [J].  Elsevier Inc. This is an open access article under the CC BY-NC-ND license

[14]Zhang Q, Xu L, Bai Y, Chen P, Xing M, Cai F, Wu Y,  Song W. “Intermittent hypoxia-induced enhancement of sociability and working memory associates with CNTNAP2 upregulation." [J]. Front. Mol. Neurosci. 16:1155047.

[15]Chen Zhang, Yue Sun, Yingying Guo, Jingjing Xu, Haiyan Zhao. “JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension." [J]. Cell Death Discovery (2023) 9:98.

MFN2-mediated mitochondrial fusion facilitates acute hypobaric hypoxia-induced cardiac dysfunction by increasing glucose catabolism and ROS production,Biochimica et Biophysica Acta (BBA) - General Subjects,Volume 1867, Issue 9,2023,130413,ISSN 0304-4165

[17]Eleutheroside E from pre-treatment of Acanthopanax senticosus (Rupr. etMaxim.) Harms ameliorates high-altitude-induced heart injury by regulating NLRP3 …N Jia, Z Shen, S Zhao, Y Wang, C Pei, D Huang… - International …, 2023 - Elsevier… The rats were placed in a hypobaric hypoxia chamber (ProOx-830, Tow-Int Tech, Shanghai,China) to mimic the environment of high-altitude hypobaric hypoxic. After the rats were …

[18]Nan Jia, Zherui Shen, Sijing Zhao, Yilan Wang, Caixia Pei, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,Eleutheroside E from pre-treatment of Acanthopanax senticosus (Rupr.etMaxim.) Harms ameliorates high-altitude-induced heart injury by regulating NLRP3 inflammasome-mediated pyroptosis via NLRP3/caspase-1 pathway,International Immunopharmacology,Volume 121,2023,110423,ISSN 1567-5769

[19]AUTHOR=Long Yanrong, Chen Hongbin, Deng Junchao, Ning Junjie, Yang Pengbo, Qiao Lina, Cao Zhongwei ，TITLE=Deficiency of endothelial FGFR1 alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice ，JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022  DOI=10.3389/fphar.2022.1039103 ，The chamber contained a continuous oxygen monitoring system (ProOX-100HE, TOW-INTTECH) 

[20]Haimei Lun, Ruochuan Liu, Qiao Hu, Yaoli Liu, Lisi Wei, Xia Liu, Dan Wu, Shangyong Zhu,Contrast?Enhanced?Ultrasonography?of?Kidney?in?Chronic?Intermittent?Hypoxia?Rat?Model,[J]Journal of Ultrasound in Medicine,2022-12-07 ,DOI:10.1002/jum.16147

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